The focus on translational research in clinical trials has the potential to generate clinically relevant genetic data that could have importance to patients. This raises challenging questions about communicating relevant genetic research results to individual patients. An exploratory pharmacogenetic analysis was conducted in the international ovarian cancer phase III trial, AGO-OVAR 16, which found that patients with clinically important germ-line BRCA1/2 mutations had improved progression-free survival prognosis. Mechanisms to communicate BRCA results were evaluated, because these findings may be beneficial to (...) patients and their families. Communicating individual BRCA results was not anticipated during clinical trial design. Consequently, options were not available for patients to indicate their preference for receiving their individual results when they signed pharmacogenetic informed consent. Differences in local requirements, clinical practice, and opinion regarding the ethical aspects of how to convey genetic results to patients are all potential barriers to returning individual BRCA results to patients. Communicating the aggregate BRCA result from this study provided clinical investigators with a mechanism to disseminate the overall study finding to patients while taking individual circumstances, local guidelines and clinical practice into account. This study illustrates the importance of increasing the clarity and scope of informed consent and the need for patient engagement to ensure clinical trial participants can indicate their preference regarding receipt of potentially important individual pharmacogenetic results. This study was registered in the NCT Clinical Trial Registry under NCT00866697 on March 19, 2009, following approval from participating ethics committees. (shrink)

This study explores how Asian American experiences are depicted in four high school U.S. history textbooks and four middle school U.S. history textbooks used in Virginia. The analytic framework was developed from the scholarship of collective memories and histories of immigration in Asian American studies. Content analysis of the textbooks suggests the overall narrative of Asian American history in U.S. history textbooks aligns with the grand narrative of American history, that is, the “story of progress.” This major storyline of Asian (...) Americans – that they suffered from nativist racism and discrimination for a long time, overcame these obstacles through their hard work and efforts, and achieved the American dream – fits well into the master narrative of American progress, highlighting the process of their belonging to the U.S. as citizens. This storyline misrepresents the realities and diversity among Asian ethnic groups and their migration histories as well as the fluid nature of their identities across national borders. These findings stress the continued challenges in representing Asian American experiences as well as other marginalized groups in U.S. history textbooks. (shrink)

This study explores how financial executives retrospectively account for their crossing the line into financial statement fraud while acting within or reacting to a financialized corporate environment. We conduct our investigation through face-to-face interviews with 13 former C-suite financial executives who were involved in and indicted for major cases of accounting fraud. Five different themes of accounts emerged from the narratives, characterizing executives’ fraud immersion as a meaning-making process by which the particulars of the proximal social context and individual motivations (...) collectively molded executives’ vocabularies of fraud immersion. Our executives’ narratives portray their fraud entanglement as typically occurring in small, incremental steps. Their accounts expand our understanding of the influence of socialization on executive-level financial fraud beyond the individualized focus of the fraud triangle model. (shrink)

We test competing theoretical perspectives of family firm governance in two separate studies by investigating whether family firm control moderates the detrimental effect of a management training ground on internal auditor objectivity and on the external auditor’s decision to rely on the internal audit function. In Study 1, we assess the objectivity of internal auditors working under an IAF that serves as a MTG or non-MTG and located in a family or non-family firm. A key result of Study 1 is (...) the mitigating role of family firm control, as we find that the objectivity of internal auditors is reduced when the IAF serves as a MTG but only in non-family firms. When the IAF is located in a family-controlled firm, the objectivity of internal auditors is unaffected by the opportunity to be promoted into management positions outside of the IAF. In Study 2, we utilize a controlled laboratory experiment with experienced Big 4 auditors as participants and examine their decision to rely on an IAF when it serves as a MTG. Our analyses indicate that external auditors reduce their reliance on non-family firm IAFs that are also MTGs and their decision is fully mediated by the perceived objectivity of non-family firm internal auditors. In contrast, external auditors’ reliance on family firm IAFs and their perceptions of internal auditor objectivity are unaffected under a MTG regime. The results of Studies 1 and 2 provide support for the alignment perspective of family firms. (shrink)

SUMMARYHaving first met in 1835, John Stuart Mill and Alexis de Tocqueville began ‘an extremely interesting and mutually laudatory correspondence'; but their splendid friendship did not last. A popular thesis focuses on letters exchanged in 1840 to 1842 that reflect conflicting views on the Eastern Question and argues that Mill initiated the ‘strange interruption’. Given Mill's commitment to the ‘agreement of conviction and feeling on the few cardinal points of human opinion’ as a prerequisite of genuine friendship, such interpretation sounds (...) plausible. However, circumstantial evidence, most notably Mill's willingness to have a frank discussion with Tocqueville on pending issues, contradicts the assertion that Mill was enraged by Tocqueville's 1841 letter. This essay suggests focusing attention on two additional cardinal differences between them—their contrasting views of François Guizot and confrontation vis-à-vis benevolent imperialism. Moreover, personal matters such as Harriet Taylor's dislike of Tocqueville and Mill's departure from the London and Westminster Review are also believed to have largely led to Mill discontinuing correspondence with Tocqueville. (shrink)

This exploratory study investigates the ways in which secondary U.S. history teachers who attended two iterations of a teacher professional development workshop, focusing on the history of school desegregation in Virginia, planned to teach the history of school desegregation through historical inquiry. Conceptualizing the history of school desegregation as difficult history, the authors conducted the content analysis of 23 written lesson plans generated by workshop participants. The historiography of school desegregation, and research on four dimensions of historical inquiry such as (...) Change and Continuity, Causation, Multiple Perspectives and Historical Sources, guided the data analysis. The findings suggest that teachers in this study were most likely to design their inquiry around Causation, framing the history of school desegregation within the classical timeline of the Civil Rights Movement, which begins with the Brown v. Board of Education decision (1954) and ends with the Civil Rights Act of 1968. What was often absent in these inquiries was Massive Resistance, the backlash against the Brown v. Board of Education decision, collective and political actions of African American communities to implement the Brown decision, and varying perspectives within African American communities as well as Whites who opposed the Brown decision. Implications for theory and practice are discussed. (shrink)

Background: Truth-telling toward terminally ill patients is a challenging ethical issue in healthcare practice. However, there are no existing ethical guidelines or frameworks provided for Chinese nurses in relation to decision-making on truth-telling of terminal illness and the role of nurses thus is not explicit when encountering this issue. Objectives: The intention of this paper is to provide ethical guidelines or strategies with regards to decision-making on truth-telling of terminal illness for Chinese nurses. Methods: This paper initially present a case (...) scenario and then critically discuss the ethical issue in association with ethical principles and philosophical theories. Instead of focusing on attitudes toward truth disclosure, it aims to provide strategies regarding this issue for nurses. It highlights and discusses some of the relevant ethical assumptions around the perceived role of nurses in healthcare settings by focusing on nursing ethical virtues, nursing codes of ethics, and philosophical perspectives. And Confucian culture is discussed to explicate that deontology does not consider family-oriented care in China. Conclusion: Treating each family individually to explore the family’s beliefs and values on this issue is essential in healthcare practice and nurses should tailor their own approach to individual needs regarding truth-telling in different situations. Moreover, the Chinese Code of Ethics should be modified to be more specific and applicable. Finally, a narrative ethics approach should be applied and teamwork between nurses, physicians and families should be established to support cancer patients and to ensure their autonomy and hope. Ethical considerations: This paper was approved by the Ethics Committee of The Second Affiliated Hospital of Guangzhou Medical University. The authors have obtained consent to use the case study and it has been anonymised to preserve the patient's confidentiality. (shrink)

This paper traces the origins of the concept of permaculture and discusses the sustainability of permaculture itself as a form of alternative agriculture. The principles of permaculture are shown to have many views and perspectives in common with Taoism and with Buddhist ecology and economics. The amalgamation of these Oriental traditions can be translated into the Kaya equation and beyond. It is argued that future permaculture movements should focus on revitalising the communitarian spirit of traditional farming villages instead of building (...) intentional communal communities. The paper also calls for more aggressive environmental-policy measures that support permaculture and internalise the non-market value of reduced fossil-fuel energy consumption and waste recycling. (shrink)

The gist of this paper is to closely examine the actual demands of the students under the education of philosophy, and execute such a philosophy education as to meet the demands, so that any plan of securing the proper status of philosophy education in the university society might be made. While it says that the philosophy education should be newly programmed, such a new programming cannot be talked about without considering the new trends or framework in the university education on (...) the whole, which is called the “convergence education.” In case the convergence education is highlighted more intensively, the significance of the philosophy education becomes prominent more and more, and this is very encouraging thereto. (shrink)

21世紀人類新科學、新文明的基礎——思維科學理論體系的建立 1687年英國科學家牛頓發表的《自然哲學的數學原理》一書，是近代自然科學完全確立的標誌，從而引領人類的科學邁入宏觀科學的時代，為現代文明奠定了理論和思想上的基礎；1905年德國科學家愛因斯坦發表的《相 對論》，更使得人類的科學邁入微觀科學的時代，讓人們對周圍世界有了一個更加深入和全面的了解。 雖然上述二者都有力地推動了人類科學和文明的巨大進步，卻都未能跳脫出現代科學的物質觀對人們思維上的限制，不能應用於高度複雜的人體和生命科學，更不能解決當前擺在人們面前諸於癌症、愛滋病、各種慢性病、遺傳病 、傳染病等形形色色的問題。 毫無疑問，21世紀將是人體和生命科學的世紀。然而，在人體和生命科學領域，尚未出現像牛頓的《自然哲學的數學原理》和愛因斯坦的《相對論》那樣具有劃時代意義，且與生命科學高度複雜的基本特點互相呼應的全新理論 體系；這就導致人體和生命科學在21世紀的發展將缺乏理論上的立足點，人體和生命科學新的大發展正在呼喚全新理論的出現。 2012年，《生命科學的哲學原理》一書的完成和發表，正是適應這一時代的需要而建立起來的全新科學理論體系，採用了與牛頓和愛因斯坦完全不同，更加高級、全新的思維方式，並突破了現代科學的物質觀對人們思維上的 限制，從而引領人類的科學從當前具體的物質科學邁入抽象的思維科學的新時代，進而有效地解決人體和生命科學領域中各種高度複雜的問題，整個人類的文明也將因此而再次發生翻天覆地的偉大轉變，為新的歷史時期之人類社 會的和平、穩定與快速發展提供理論和思想上的依據。.

On the premise that the good knowing is the originary reality, this article provides a synopsis of Wang Yangming’s exposition of the fundamental essence of liangzhi. The self-existent resemblances of the originary reality are outlined and summarized as the eight virtues of liangzhi: voidness, intelligence, luminousness, awareness, constancy, happiness, true I, and purity. These eight virtues are, however, ultimately subsumed by the middle, which governs them in common. The middle is the original state and true form of the fundamental essence (...) of liangzhi, which Wang Yangming describes as a transparent mirror and level balance. (shrink)

Business Ethics, the Environment & Responsibility, EarlyView.

In this paper, I develop an account of appreciation. I argue that appreciation is an epistemic emotion in which the subject grasps the object in an affective way. The “grasping” and “feeling” components implies that in appreciation, we make sense of the object by having cognitive control over it, are motivated to maintain the valuable epistemic state of understanding, and experience the “aha” or “eureka” moment. This account offers a unified account of the many types of appreciation, including the aesthetic, (...) the moral, and the epistemic. In all these cases, appreciation requires some other first-order emotions as prerequisite. (shrink)

The study compares the changes in the theory of Marxism that took place in Europe (in the form of neo-Marxism and its movements, in particular the Frankfurt School) and the Sinicized version of Marxism. The study also examines how Sinicized Marxism was reflected in the political discourse and political philosophy of modern China (People’s Republic of China) and is reflected in social policy in the country. Studying the influence of socio-economic changes and the history of the people on ideological changes (...) allows us to identify several principles of Sinicized Marxism, which on an ongoing basis determine social policy and foreign relations. This is, first, etatism and the dominance of state interests over private ones, which limits human rights and national self-determination, but preserves the integrity and stability of the state, which protects the interests of the people. (shrink)

Supply networks as complex systems are significant challenges for decision-makers in predicting the evolution of cooperation among firms. The impact of environmental heterogeneity on firms is critical. Environment-based preference selection plays a pivotal role in clarifying the existence and maintenance of cooperation in supply networks. This paper explores the implication of the heterogeneity of environment and environment-based preference on the evolution of cooperation in supply networks. Cellular automata are considered to examine the synchronized evolution of cooperation and defection across supply (...) networks. The Prisoner’s Dilemma Game and Snowdrift Game reward schemes have been formed, and the heterogeneous environment and environmental preference have been applied. The results show that the heterogeneous environment’s degree leads to higher cooperation for both Prisoner’s Dilemma Game and Snowdrift Game. We also probe into the impact of the environmental preference on the evolution of cooperation, and the results of which confirm the usefulness of preference of environment. This work offers a valuable perspective to improve the level of cooperation among firms and understand the evolution of cooperation in supply networks. (shrink)

Objectives: Self-compassion functions as a psychological buffer in the face of negative life experiences. Considering that suicidal thoughts and behaviors and non-suicidal self-injury are often accompanied by intense negative feelings about the self, self-compassion may have the potential to alleviate these negative attitudes and feelings toward oneself. This meta-analysis investigated the associations of self-compassion with STBs and NSSI.Methods: A literature search finalized in August 2020 identified 18 eligible studies, including 8,058 participants. Two studies were longitudinal studies, and the remainder were (...) cross-sectional studies. A random-effects meta-analysis was conducted using CMA 3.0. Subgroup analyses, meta-regression, and publication bias analyses were conducted to probe potential sources of heterogeneity.Results: With regard to STBs, a moderate effect size was found for self-compassion. Positively worded subscales exhibited statistically significant effect sizes: self-kindness, common humanity, and mindfulness. For NSSI, a small effect size was found for self-compassion. There was a large heterogeneity, and publication bias was minimal. Subgroup analysis results showed that sample characteristic was a moderator, such that a larger effect size was witnessed in clinical patients than sexually/racially marginalized individuals, college students, and healthy-functioning community adolescents.Conclusions: Self-compassion was negatively associated with STBs and NSSI, and the effect size of self-compassion was larger for STBs than NSSI. More evidence is necessary to gauge a clinically significant protective role that self-compassion may play by soliciting results from future longitudinal studies or intervention studies. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:RusselL on Chinese Civilization 23 RUSSELL ON CHINESE CIVILIZATIONI Yu DONG Ph}losophy / McMaster University Hamilton, Ont., Canada L8s 4K1 1 I am indebted to Nicholas Griffin for his valuable comments and encouragement. I thank Marty Fairbairn and Perer Lovrick for many corrections in the paper. I am also greatly indebred to Ken Blackwell for his helpful criticisms and suggesrions. • (London: Allen & Unwin, 1922), p. 20. (...) 3 Karl Popper, The Open Society and Its Enemies (Princeron: Princeton U. P.), p. 173· B ertrand Russell arrived in China with Dora Black in October 1920. World War I had deepened his disillusionment with both the capitalist system and Western civilization in general. Seeking a socialist solution, he had visited Soviet Union just a few months before. But he had found that the Communist state there presented an unappealing alternative to the capitalist West in that it treated its citizens as slaves. The sad mood in which he "set out for China to seek a new hope"2 was described in his The Problem of China, published in 1922 after his nine-month visit: "It was on the Volga, in the. summer of 1920, that I first realized how profound is the disease in our Western mentality, which the Bolsheviks are attempting to force upon an essentially Asiatic population, just as Japan and the West are doing in China" (p. 18). The 1920S were a time when China, both as a nation and as a civilization, was in deep trouble. Her young people were eagerly looking outside their country to find a way of saving her. Since the 1840 Opium War, the Western Powers had poured into China, which had been a closed society, at least in Karl Popper's sense,3 for more than 3,000 years. With the collapse of the Qing dynasty in 19I1, China had been thrown into a state of anarchy by feuding warlords. The Great World Powers had both politically and economically dominated China through successive wars with her;4 through demanding indemnities, the cession of territory, fixed tariffs, etc.; and through controlling the corrupt and inept central government and warlords. Meanwhile, China was plagued by famine, piracy, brigandage, incipient rebellion,5 and the failures of various attempts at reform and revolution.6 China was well on the way toward disintegration, divided into "spheres of influence" by Britain, Germany, France, Russia and, especially, Japan. In the 1920S, China was also in the period of the May Fourth Movement-named after a popular student protest on 4 May 1919against foreign imperialism and an impotent Chinese government. It was agitated by the Treaty of Versailles which transferred, at the request ofJapan, the properties and privileges of the German sphere of influence in the Shandong Peninsula to Japan. This movement advocated learning science and adopting democratic principles in order to save China. It is important in Chinese history as a symbol of Chinese awareness of the need for the most profound changes in her tradition. All of these factors constituted the background to Russell's visit to China and thus affected the formation of his distinct view of the problem of China.? The invitation to him was a part of Chinese efforts in seeking methods from the West to save their country. Russell had already been known in China as a great philosopher, not only for his philosophy of logic and science, but also for his views on social problems. Some Chinese had access to his books: Principles ofSocial Reconstruction (1916), Political Ideals (1917), Roads To Freedom (1918), and magazine publication of parts of The Practice and Theory ofBolshevism (1920).8 Considering this background, it is quite understandable why 4 For example, Brirain and France 1856-60, Japan 1894-95, 1914-15. 5 For example, Taiping 1850-65, and the Boxer Rebellion of 1900. 6 The revolution of 1911 actually just changed the name of the government, rather than the reality of society. 7 A detailed description of this background as "psychological roots" can be seen in S. P. Odgen, "The Sage in the Inkpot", Modern Arian Studies, 16 (1982): 529-600. 8 For example, Zhang Shenfu, a student originally majoring in mathematics in Beijing University, had read almost all of... (shrink)

In this paper, we employ Weibo Index as the proxy for investor attention and analyze the relationships between investor attention and stock market performance, i.e., trading volume, return, and volatility. The empirical results firstly show that Weibo attention is positively related to trading volume, intraday volatility, and return. Secondly, there exist bidirectional causal relationships between Weibo attention and stock market performance. Thirdly, we generally find that higher Weibo attention indicates higher correlation coefficients with the quantile regression analysis.

Previous studies have demonstrated positive correlations between children’s interpersonal trust and social adjustment. However, the psychological mechanism underlying this effect is still unclear. The current study tested the indirect roles of teacher–student relationships from both students’ and teachers’ perspectives in a Chinese context. In total, 709 pupils from grade three to grade five, and their 17 head teachers from a Chinese public primary school participated in this study. The Children’s Generalized Trust Beliefs Scale, Social Adjustment Scale for Children and Adolescents, (...) and Teacher–Student Relationship Questionnaire were used in this study. All these variables were correlated with each other. Structural equation models showed that the interpersonal trust indirectly influenced social adjustment through the teacher–student relationship from students’ perspectives, while the teacher–student relationship from teachers’ perspectives did not play an indirect role. These findings suggest that the teacher–student relationship perceived by students is more important for children’s social adjustment than that perceived by teachers. Both parents and teachers should pay more attention to developing children’s interpersonal trust, build better teacher–student relationships, and focus more on how children feel about the relationship. (shrink)

Justin D’Arms and Daniel Jacobson have argued that to evaluate the funniness of a joke based on the consideration of whether it is morally appropriate to feel amused commits the “moralistic fallacy.” We offer a new and empirically informed reply. We argue that there is a way to take morality into consideration without committing this fallacy, that is, it is legitimate to say that for some people, witty but immoral jokes can fail to be funny because they are immoral. In (...) our account, one has an intramural moral reason not to feel amused if one focuses on the moral feature itself of a joke rather than the moral consequence implied in one’s reaction to the joke. When one judges a joke as not funny because of the intramural moral reason, one is in a negative emotional state with high arousal, for example, moral disgust or anger. This state is psychologically incompatible with amusement. That one has an intramural reason not to feel amused thus implies that one does not have a reason to feel amused. Moral consideration thus plays an indirect and appropriate role in the evaluation of the funniness of a joke. (shrink)

A long-standing problem in biology, economics, and social sciences is to understand the conditions required for the emergence and maintenance of cooperation in evolving populations. This paper investigates how to promote the evolution of cooperation in the Prisoner’s Dilemma game. Differing from previous approaches, we not only propose a tag-based control mechanism but also look at how the evolution of cooperation by TBC can be successfully promoted. The effect of TBC on the evolutionary process of cooperation shows that it can (...) both reduce the payoff of defectors and inhibit defection; although when the cooperation rate is high, TBC will also reduce the payoff of cooperators unless the identified rate of the TBC is large enough. An optimal timing control of switched replicator dynamics is designed to consider the control costs, the cooperation rate at terminal time, and the cooperator’s payoff. The results show that the switching control between an optimal identified rate control of the TBC and no TBC can properly not only maintain a high cooperation rate but also greatly enhance the payoff of the cooperators. Our results provide valuable insights for some clusters, for example, logistics parks and government, to regard the decision to promote cooperation. (shrink)

Abstract:Retro-writing has ethical implications. How a speaking subject applies a retro-perspective frames a piece of writing within certain cultural discourses. In contemporary Chinese poetry, cultural nostalgia and the attempted revival of ancient aesthetics is a complex issue, one that is largely the result of a general interest in cultural archeology, writers’ anxiety of influence, the desire to escape from various political pressures, and the claim of a need for a distinctive Chinese cultural identity. The subject in many contemporary Chinese poems, (...) in many cases, is a male subject striving to retrieve the premodern holistic state of being, which is illusory. Han Bo’s two poems “Modern Sex Machine” and “Mass(ive) Killing Machine” are unique in that they examine the bludgeoning of modernity within postmodern parameters and attempt to map the dynamics of modern and contemporary subjecthood, which is in fact a transcorporeal experience of the subject as that which is, ultimately, subjectless. Such work, in creating a cross-corporeal subjectless subject, embraces alterity and renders possibilities for the reader to reject a prior unitary transcendental subject that is illusory, and thereby to discover the beings of themselves and their roles in the world—and to extend this work of reconfiguring subjecthood from literature into other aspects of social life. (shrink)